![]() ![]() Metabolised in the liver by hydrolysis with the formation of salicylic acid with subsequent conjugation with glycine or two drugs. The presence of food in the stomach significantly affects the absorption of Monit-AS (Aspirin). When administered orally Monit-AS (Aspirin) is rapidly absorbed mainly from the proximal small intestine and to a lesser extent from the stomach. The blockade of COX-1 in the mucosa of the stomach leads to inhibition of gastroprotective prostaglandins, which may lead to ulceration of the mucous membrane and subsequent bleeding. It stimulates the excretion of uric acid (violating its reabsorption in the renal tubules) but in high doses. Increases the rate of hemorrhagic complications in carrying out surgical procedures, increases the risk of bleeding during therapy with anticoagulants. Monit-AS (Aspirin) increases fibrinolytic activity of plasma and reduces the concentration of vitamin K-dependent coagulation factors (II, VII, IX, X). At a daily dose of 6 g or more inhibits the synthesis of prothrombin in the liver and increases the prothrombin time. ![]() It is effective in primary prevention of cardio-vascular system and secondary prevention of myocardial infarction. Reduces mortality and risk of myocardial infarction in unstable stenocardia. Reduces aggregation, platelet adhesion and thrombus formation through suppression of synthesis of thromboxane A2 in platelets. Analgesic effect of Monit-AS (Aspirin) is due to both central and peripheral effects. Reduction of prostaglandins (mainly E1) in the thermoregulation center leads to a decrease in body temperature due to expansion of blood vessels of the skin and increase perspiration. The mechanism of action is associated with inhibition of COX activity - the main enzyme metabolism of arachidonic acid which is a precursor of prostaglandins which play a major role in the pathogenesis of inflammation, pain and fever. It has anti-inflammatory, analgesic and antipyretic effect, and inhibits platelet aggregation. ![]()
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